Excellent analysis of the Fahy/Horvath paper @AgingCell & in the media last week indicating reversal of biological age from a cocktail of rhGH, metformin, DHEA.
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Excellent analysis of the Fahy/Horvath paper @AgingCell & in the media last week indicating reversal of biological age from a cocktail of rhGH, metformin, DHEA.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
He uses growth hormone, which is known to raise blood sugar levels, we talked about that as a downside, but then he realized if he could include DHEA, a hormone that is depleted during aging, as well as Metformin, he could mitigate the negative effects of growth hormone. And he gave that for 12 months to 10 healthy men that were aged 51 to 65, and lo and behold, when he looked at the biological clock of those men, they went back two and a half years.
And what he showed after a year of this treatment was that the epigenetic clock measured by Horvath, remember, this is the DNA methylation patterns, reset