Peter Attia· MD
I have to think there's something associated with the benefits of how lactate is consumed during exercise so yeah this is a this is of interest in the literature now people are doing lactate clamps on people and uh looking for increases in mitochondrial protein expression and what are they seeing there's sometimes yes and sometimes no this this sounds a lot like amino acids has to do with the endogenous for versus the exogenous because you get a completely different signal so it's the endogenous lactate when it's high seems to stimulate mitochondrial biogenesis rather than just infusing it okay but why would that be well a lot of these pathways are redo sensitive ah okay so make sure I want to make sure the listener understands that that's a very important point because it's redo sensitive that's just fancy speak for saying it depends on the amount of protons or pH balance of what's going on and if you just give somebody lactate without actually creating the slight alteration in PH that is naturally going to be accompanied by exercise you don't reap the benefits whereas if the lactate is produced in in in in concert with exercise you get the lactate but you also get the pH pertubation that is the the key to unlock its potential