Peter Attia· MD
yes there is a competition among substrates and lactate shuts the door for fatty acid metabolism
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
yes there is a competition among substrates and lactate shuts the door for fatty acid metabolism
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the path of degradation of lactate is to generate this acetal COA and that inhibits the enzymes of that transport aceto COA or fatty acids into the mitochondria so lactate basically shuts the door blocks fatty acid metabolism so it inhibits and inos and I have shown this uh bux the cpt1 and two the carnitine palate Transporters these are Transporters that allow fatty acids to get into the mitochondria for oxidation