Fructose inhibits carnitine palmitoyltransferase 1 (CPT1), which is responsible for shuttling fatty acids into mitochondria for beta-oxidation.

“fructose does a metabolite of fructose called methyl bioxy MGO sits in the active site of the gamma subunit of that kinas and actually binds to arginines in that active site rendering that uh uh enzyme now dead it's an irreversible inhibition because of the calent bonding of that methylglyoxal that alahh to the Arginine and now that enzyme is dead Okay so it basically acts like a key that doesn't turn the lock but prevents the the key that you want in that lock from entering the lock it's like it's like gluing a lock shut yeah got it right so that's one of the enzymes that's one okay second one aad L ailoa dehydrogenase long chain so this is necessary to cleave two carbon fragments of fatty acids to prepare them for U uh metabolism so it inhibits that one and then finally it inhibits carnitine pidal transferase one now cpt1 now that's the enzyme that regenerates carnitine carnitine is the shuttle mechanism by which you get the uh fatty acids from the outer mitochondrial membrane through to the inner mitochondrial membrane so that they can be beta oxidized for energy so if you don't have that c cpt1 you're basically carnitin lless and therefore you can't generate um beta oxidation all right Mike fructose mitochondrial poison yeah”