Paul Saladino· MD
when a cardiolipin molecule is comprised of linoleic acid it gets the ability to deform the cardiolipin or the cytochrome c molecule exposing the cardiolipin to the iron molecule and thus oxidizing the linoleic acid
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
when a cardiolipin molecule is comprised of linoleic acid it gets the ability to deform the cardiolipin or the cytochrome c molecule exposing the cardiolipin to the iron molecule and thus oxidizing the linoleic acid
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in the mitochondria linolenic acid is actually able to auto oxidize right when it auto oxidizes it releases these metabolites which we will get to the metabolites can then go into adjacent cardiolipin uh molecules and cause them to break down
oxidation the the damage to the cardiolipin is an oxidative process right so you have in the mitochondria reactive oxygen species that are being generated these can go in oxidized linoleic acid in the cardiolipin them thereby breaking the cardiolipin
scientists have gone in and replaced linoleic acid with oleic acid and done various other similar experiments cardiolipin are only subject to this sort of oxidative damage when they're comprised of linoleic acid