Individuals with mitochondrial disease struggle to enter a restorative state during sleep due to impaired parasympathetic nervous system activation, potentially decreasing lifespan by three decades.

“So uh some of the biggest difference we see between mitochondrial disease and people who have normal healthy spectrum of mitochondria is this inability to slow down and to go into this restorative state at night. Uh so that that positions mitochondria in in the context of restoration and you know the our ability to heal and uh and the and lifespan in those people is is decreased by about three decades.”