Peter Attia· MD
and um over many years mitochondrial the mitochondria get less good at making the energy because of damage recurrent damage and it's thought that oxidative stress to the mitochondria can cause this damage and so when you're eating uh when you want to try to store fat mitochondrial oxidative stress is part of the requirement to store fat and fructose works to store fat by stimulating mitochondrial oxidative stress and initially that is a reversible very easily reversible mechanism the oxidative stress goes on it it's in inhibits these enzymes and it leads to fat production and and so forth so it's a it's a survival pathway right but what happens is um if you keep stimulating mitochondrial oxidative stress and it's been shown with fructose for example the mitochondria start to decrease and um and the mitochondrial change they become smaller and less efficient and what happens is the mitochondrial function starts to to to to reduce a number and and so you have less mitochondria when that happens you can you make less atp