Dopamine is a depletable but replenishable resource.

“So now we've given some meat to this thing that we call the pleasure pain balance, and now it should make perfect sense why if you take something or do something that leads to huge increases in dopamine, afterward your baseline should drop because there isn't a lot of dopamine around to keep your baseline going.”

“we have a dopamine Baseline our dopamine Baseline is our reservoir of dopamine it's how full or empty our dopamine pool is”

“I think what when we look at the the neurobiological literature on dopamine, we're going to realize that yeah, of course, addictions spend out your dopamine, drop your baseline, your your bank account is in the red, deep in the red.”

“first of all dopamine is a depletable but replenishable resource in other words unless the dopamine neurons are destroyed like in a case like Parkinson's or rare you know exposure to neurochemical that are involved in you know certain pesticides and that's not a dig on certain pesticides per se but there's a history there of people you know taking certain compounds in and destruction of of dopamine neurons those particular cases aside most of us have dopamine neurons that can readily release dopamine and do so at what I would call a tonic level it's kind of what we could just refer to as a baseline level of dopamine neurons firing in the background just firing off Action potentials electrical signals releasing dopamine into the various circuits that they're trying to modulate”