Andrew Huberman· PhD
When somebody pursues a drug or an activity that leads to huge increases in dopamine. And now you understand that afterward the baseline of dopamine drops because of depletion of dopamine, that readily releasable pool. The dopamine is literally not around to be released, and so people feel pretty lousy and many people make the mistake of then going and pursuing the dopamine evoking the dopamine releasing activity or substance again thinking mistakenly that it's going to bring up their baseline.