Exercise stimulates the release of BDNF in the brain via the bloodstream and via ketones released by the liver.

“So it got into the the uh rarified very protected bloodstream of inside the brain and that myioine stimulated the release of BDNF in the brain. That's pathway number one. Pathway number two comes through the liver. Uh because exercise is a stress on generally. Uh how do we know that? Well, cortisol is released whenever we exercise it. We we need we need uh that sugar uh in our blood. And so so that's how the physiological um mechanisms work. And so um there is a uh ketone um beta hydroxybutyrate that we've known for a very long time that gets released by the liver during exercise. And we also know that that particular ketone passes that bloodb brain barrier and it's another stimulant for BDNF.”