David Sinclair· PhD
And NAD is consumed by CD38 during aging (in mice at least), making Sirtuins even less active.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
And NAD is consumed by CD38 during aging (in mice at least), making Sirtuins even less active.
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this is the work of Eduardo Chini who was the first one to show that CD38 appears to be the major driver of the decrease of NAD during aging.