David Sinclair· PhD
In the aged rats, increased NAD+ levels were claimed to improve muscle mass, vascularization, muscle cell stemness, and treadmill endurance
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
In the aged rats, increased NAD+ levels were claimed to improve muscle mass, vascularization, muscle cell stemness, and treadmill endurance
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This new paper @Cell_Metabolism shows ET increases NAD+ levels in muscle & stress resistance, and reduces age-related biomarkers, ostensibly by producing more H₂S (rotten egg gas) via cystathionine gamma-lyase (CSE), activating of metabolic enzymes that raise NAD+ in muscle