David Sinclair· PhD
An antibody directed to the NAD-degrading enzyme CD38 in mice restores metabolic fitness, improves cognitive performance & lowers neuroinflammation https://t.co/6BHaD9zJqk https://t.co/4GbLBOriTH
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
An antibody directed to the NAD-degrading enzyme CD38 in mice restores metabolic fitness, improves cognitive performance & lowers neuroinflammation https://t.co/6BHaD9zJqk https://t.co/4GbLBOriTH
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so you have a situation during aging where CD38 increases is you increase the degradation and so you decrease the pool of NAD
if you study a mouse that's knocked out for CD38, you find that ND levels actually do not decrease during aging.