Sirtuins require NAD to deacetylate lysine residues, which is important for DNA integrity and managing oxidative stress.

“these guys discovered that there are other chemicals besides this acid acid toll it's like acetic acid and acetic Group but there is ugly or others like butyl all right carbonyl besides acetyl a settled groups”

“cerin are proteins that require NAD to deacetylase lysing residues which is just fancy chemical talk for it it changes the modification of of an amino acid but but this is something that occurs so much and is so important to maintaining DNA integrity and managing oxidative stress”

“so um basically cerin are proteins that require NAD to deacetylase lysing residues um which is just fancy chemical talk for it it changes the modification of um of an amino acid but but this is something that occurs is so much and is so important to maintaining DNA integrity and managing oxidative stress”

“Um there's enzymes called certuins that use NAD. Um they very often remove a small modification on protein lysines. So acetil modifications on lysines, asil groups on lysines, suanil groups on lysines. That's usually something to do with enzyme regulation, gene regulation. As you said, classically, there's a lot of gene silencing that is done with with uh this this reaction.”