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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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How effective is NAD and its precursors for longevity? — Whalespan

Content›Video›How effective is NAD and its…

How effective is NAD and its precursors for longevity?

Peter Attia10m · 2024-05-17

Claims Made

13

Claims Supported

5

Support Rate

38%

Support rate

5 of 13 claims supported

5 supported8 partial / not

Claims from this content

11

✕Not SupportedPeter Attia is unconvinced that oral supplementation of NR or NMN benefits human health.◐Partially SupportedNAD+ precursors like nicotinamide riboside (NR) are broken down in the gastrointestinal tract, primarily into nicotinic acid (niacin), when taken orally.?Limited ResearchThere is a lack of evidence that raising NAD levels in humans will correct a problem or produce a positive benefit, despite NAD levels declining with age.✓Well SupportedSirtuins require NAD to deacetylate lysine residues, which is important for DNA integrity and managing oxidative stress.Not Supported

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Peter Attia on Zone 2 Cardio

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Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✕

Peter Attia believes NAD and its precursors are currently 'noise' in the context of geroprotection.

✓Well SupportedNAD is a crucial molecule involved in metabolism, cell signaling, DNA repair, and age-related diseases.

◐Partially SupportedA combination of NR and terban showed a delay in symptom progression in ALS patients in a Phase 1 study.

◐Partially SupportedA combination of nicotinamide and terban showed a short delay in disease progression in a small study of ALS patients.

◐Partially SupportedA study on NAD+ use in mild cognitive impairment showed improvements in physical function but not cognitive impact.

◐Partially SupportedThe probability that NAD and its precursors are geroprotective is very low, but not zero.

◐Partially SupportedA small study in 20 Parkinson's disease patients, with 10 on NR and 10 on placebo for four weeks, showed some change in a movement disorder rating scale, but was confounded by patients being closer to their levodopa dose.