There is a lack of evidence that raising NAD levels in humans will correct a problem or produce a positive benefit, despite NAD levels declining with age.

“but whether it raises NAD sufficiently to have the broad effects of other “NAD boosters” will require more study.”

“you haven't even bought the first hypothesis which is even if i could magically deliver 20 more nad to a 50 year old you're not you're not sounding very convinced that that's going to improve quality or length of life yeah not at this point in time right”

“I think it's safe to say we don't yet know the answer to that but nevertheless um I you know I I think a cottage industry around NAD has come up which says look we know the answer to this or at least we're going to postulate that the answer is of course NAD is going down with age um and whether or not that's causal or not giving more NAD is going to be a better thing”

“the data is decidedly mixed both in the literature uh pre-clinical literature and in people as to whether or not boosting NAD increases lifespan improves Health span”

“How could it be that supplementing NAD does not lead to a longer, better life or some health benefit?”

“Um, that's a logical conclusion right now. Well, not completely because uh you are assuming you know it it depends also what is the reason why NAD levels decrease.”

“How could it be that supplementing NAD does not lead to a longer, better life or some health benefit?”