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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Do resveratrol and NAD precursors promote longevity? — Whalespan

Content›Video›Do resveratrol and NAD precu…

Do resveratrol and NAD precursors promote longevity?

Peter Attia8m · 2025-02-02

Claims Made

13

Claims Supported

2

Support Rate

15%

Support rate

2 of 13 claims supported

2 supported11 partial / not

Claims from this content

11

?Limited ResearchThere is a lack of evidence that raising NAD levels in humans will correct a problem or produce a positive benefit, despite NAD levels declining with age.✓Well SupportedNAD+ levels decline dramatically with age.◐Partially SupportedLifespan extension studies may be flawed if control groups were short-lived.◐Partially SupportedMice in an original resveratrol study died from severe fatty liver disease compressing their lungs, not from aging.✕Not Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Peter Attia believes NAD and its precursors are currently 'noise' in the context of geroprotection.

✕Not SupportedNMN supplementation in aged mice has been shown to cause kidney inflammation and potential pathology.

?Limited ResearchIt is unclear if oral NAD precursors like NMN, NR, niacin, and nicotinamide can achieve effective doses in humans due to breakdown to niacin in the gut.

✓Well SupportedBoosting NAD+ may increase lifespan and improve healthspan, with positive data from studies in mice showing lifespan extension.

✕Not SupportedResveratrol has not been shown to affect the biology of aging or act as a longevity drug.

✕Not SupportedThere is insufficient data and lack of well-controlled clinical studies to definitively support the efficacy of NAD+ precursors like NMN or NR.

✕Not SupportedSubsequent studies with longer-lived controls did not replicate Johan A's lab findings that NAD+ boosting increased lifespan.