NAD+ levels decline dramatically with age.

“The field of longevity research has homed in on NAD+ as a potential therapy because of evidence that our levels decline as we get older, which may also contribute to the risks of age-related diseases, says Dr. Shalender Bhasin @ Brigham and Women's Hospital”

“the NE d levels decline really dramatically as you get older and one of my friends is one of the prominent nad researcher and it's done a lot of these studies some of the best studies out there actually and documenting this decline this dramatic decline as you age and so so say a 30 healthy 34 year old might have a level of 44 there nad I'm not sure what the units are but by the time you get to 80 most eight-year-olds are was below one below one so it's not just a little bit lower it's like almost unmeasurable lower”

“as we age it goes down”

“NAD you know like Steve said Central molecule and thousands of chemical reactions really important good reason I know about good reason some reason to believe that NAD homeostasis declines with age like lots of many other things so it's plausible that if you fix that you can get benefits from it”

“so important fact that without it life would cease to exist the NAD boosters nicotinamide right aside and nicotinamide mononucleotide at very high doses in animal studies have been shown to improve the way multiple tissues and cell types age including the heart and skeletal muscle the brain and stem cells”

“but the possibility that intracellular nad levels can be increased with the supplement or several types of supplements is very interesting if not downright exciting for one simple reason nad levels decrease with age and a decrease in nad levels across multiple types of tissues is associated with many and I mean many hallmarks of aging”