The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
we can also make an ad from nicotinamide ribosome which is NR which a lot of people have heard about in our diet or theirs that's the only present in small amounts usually nicotinic acid is the main form and then as you've suggested there's another molecule called nm n which is nicotinamide mono mono nucleotide and that is formed from an R in our body so we we digest NR we absorb NR it becomes n MN n MN is then recycled back is then turns into nad
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
what is your take right now based on the state of the science that we have which admittedly I think we're just scratching the surface of as far as first and foremost just at the mechanistic level do what is your belief that orally administered nicotinamide ride beside can actually make it into a cell I don't if you've seen it but Josh Rabinowitz his paper over the summer would suggest no
how much loss is there outside of the first pass effect is there an inefficient what are you calling loss are you calling increasing hepatic nad loss or are you calling alcohol loss anything that prevents the actual nicotinamide from making it into the cell
the amount of NR that escapes the blood is so small you need a magnifying glass to see it so it's a Pico mole or something
and also there's the complicating factor that a microbiome will love to chew up that NR probably and there's an increasing studies showing that microbiome does eat up some of the molecules that we were ingesting so that nice and part of the molecule nicotinamide it comes off pretty quickly even if a molecule in your fridge gets wet you all start to lose that knee in my bond and it'll break off and in the gut some evidence that people have published and some haven't points to the gut playing a major role in how much this actually gets into the body
nad and its precursors are broken down in the gastrointestinal tract and so you know if you take you know nr for example so nicotinamide riboside orally it mainly will enter the body in the form of nicotinic acid or niacin which is a healthy substance
but i don't really think they're fundamentally different than taking a physician-prescribed niacin pill from the perspective of providing nad precursors
it doesn't mean that you know there can't be a trickle of them entering some other way that has a physiological effect or that there's some local effect or some effect on the microbiome of taking them so they're you know biology is super complicated there are ways that these could be doing interesting health supporting things
what is the effect of the gastrointestinal tract on these agents i mean they get broken down and they get broken down um all the way to the level of nicotinic acid or niacin basically and this is the main way they enter the body
NAD itself um but I'm also speaking a little bit more broadly when I'm I'm talking about precursors cuz NAD can't be taken orally it could be given intravenously um when there are lots of clinics out there that do that but you know from a practical standpoint we tend to look at things that you can take orally so we really tend to be talking about NR and nmn which are oral precursors that become converted into NAD
Nicotinamide riboside is a form of vitamin B3 that is converted into NAD+.