Andrew Huberman· PhD
But I'm not aware of any studies that have directly linked oral NAD to NAD levels in cells and how those two things relate.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
But I'm not aware of any studies that have directly linked oral NAD to NAD levels in cells and how those two things relate.
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the other way that these things are typically delivered is through intravenous nad which says hey you don't need to make it we'll give it to you we know you can't take nad orally so you have to do it intravenously
very few people have studied taking nad orally what we've studied in humans and in mice extensively maybe not as extensively as many would like is giving precursors to nad
nad there's no way to orally take it right it has to be yeah there's no known absorption route for nad and i think it'll get broken down probably all the way to nicotinic acid although i'm not 100 sure anyone has proven that but it i certainly don't think it would enter the body any other way than either nicotinamide which is like you know a little bit closer to remaking nad or or nicotinic acid
They have a new product that's sublingual NAD. So they they don't they they specialize in technology for sublingual delivery and they make other things too. Uh so we'll just explain to folks why that matters. You can't take NAD orally because it
Do oral NAD supplements work?
well for starters nad has poor bioavailability animal studies have shown that upon ingestion orally administered nad is primarily digested into the precursor nicotinamide but also to nicotine my drive aside and one nucleotide before being absorbed
So NAD is not even getting in inside of cells essentially. You're taking it orally. There's a there's a funny thing where people started um injecting right?