The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
So that's what we've shown is that this mitochondrial dysfunction induced senescence we call it mitochondrial dysfunction associated senescence or MiDAS. So we call it the MiDAS phenotype. It really has to do with this altered NAD, NADH ratio, and that's one of the drivers.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Interestingly, so when you change that ratio, you activate a kinase called AMP kinase. AMP kinase is a major regulator of p53, p53 is a major regulator of both senescence and apoptosis.