Rhonda Patrick· PhD
Interestingly, so when you change that ratio, you activate a kinase called AMP kinase. AMP kinase is a major regulator of p53, p53 is a major regulator of both senescence and apoptosis.
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Interestingly, so when you change that ratio, you activate a kinase called AMP kinase. AMP kinase is a major regulator of p53, p53 is a major regulator of both senescence and apoptosis.
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So that's what we've shown is that this mitochondrial dysfunction induced senescence we call it mitochondrial dysfunction associated senescence or MiDAS. So we call it the MiDAS phenotype. It really has to do with this altered NAD, NADH ratio, and that's one of the drivers.