Andrew Huberman· PhD
And in fact, acetylcholine released from nucleus basalis is sort of like a gate, whereby, if you release acetylcholine, the opportunity for neuroplasticity and learning is available for some period of time.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
And in fact, acetylcholine released from nucleus basalis is sort of like a gate, whereby, if you release acetylcholine, the opportunity for neuroplasticity and learning is available for some period of time.
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But acetylcholine released from a particular nucleus in the brain, called nucleus basalis, the acetylcholine released from nucleus basalis, is what we call permissive for plasticity.
There these incredible experiments that have been done by Mike Merzenich and colleagues, showing that if you stimulate nucleus basalis to release acetylcholine and you expose an animal or a human to a particular sensory stimulus, The brain remaps very fast according to that experience.