Boosting NAD levels in the skin has beneficial effects, such as thickening, likely by activating sirtuin defenses, and molecules like nicotinamide or nicotinic acid are found in cosmetics for this purpose.

“And they've been shown to actually have quite beneficial effects on the skin. Thickening, for example. Mostly, people think it's because of the B vitamin, vitamin B3, but actually, probably what's going on is it's turning on again the sirtuin defenses of the skin.”