David Sinclair· PhD
NMN has been reported to improve depression-like behaviors in stress/corticosterone models in mice. Translation to humans is not known
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
NMN has been reported to improve depression-like behaviors in stress/corticosterone models in mice. Translation to humans is not known
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
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The NAD booster NMN (300 mg/kg for 2 wks) reduced depression in mice and stimulated energy production in the brain’s hippocampus.