Long-term dietary administration of NMN in mice with an accelerated aging phenotype mitigated age-associated physiological decline, improving skeletal muscle function, mitochondrial function, energy expenditure, bone density, and decreasing insulin resistance, with benefits occurring in a dose-dependent manner.

“A long-term study found that dietary administration of nicotinamide mononucleotide mitigated the a associated physiological decline in mice that have an accelerated aging phenotype specifically starting at five months of age mice were fed either a hundred or three hundred milligrams per kilogram body weight nicotinamide mononucleotide for twelve months these animals had improved skeletal muscle function mitochondrial function increased energy expenditure increased bone density and also decreased insulin resistance these benefits occurred in a dose-dependent manner so the higher the dose of nicotinamide modern nucleotide the greater the benefit”