David Sinclair· PhD
early results, for instance, from Yoshino et al. in 2021 showed increase insulin stimulated glucose disposal.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
early results, for instance, from Yoshino et al. in 2021 showed increase insulin stimulated glucose disposal.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
So this was a 10 week study. It's well done, it's randomized, placebo controlled. It was 250 milligrams, which is a relatively low dose. Nevertheless, it improved what you said, insulin stimulated glucose disposal. That's basically insulin sensitivity. And that's a hallmark of longevity.
So when it comes to NMN, there's been a number of animals studies showing, for instance, similar to NR, restores NAD levels, it enhances insulin sensitivity.