David Sinclair· PhD
Compared to the untreated high-fat group, NMN significantly reduced heart enlargement, fibrosis, inflammatory markers and cellular aging markers
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Compared to the untreated high-fat group, NMN significantly reduced heart enlargement, fibrosis, inflammatory markers and cellular aging markers
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the authors concluded that NMN protected the aging heart from metabolic damage, fibrosis, and restored maintenance pathways that had declined.
the NMN intervention significantly reduced the whole-body fat content (P<0.05) and hepatic fat content in high-fat diet-treated mice.