David Sinclair· PhD
Here’s a summary of the team’s new work @CellReports reversing female infertility in 🐭 using NMN to stabilize DNA.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Here’s a summary of the team’s new work @CellReports reversing female infertility in 🐭 using NMN to stabilize DNA.
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NAD boosting by NMN is thought to reverse infertility by increasing the activity of SIRT2, which controls the spindles that divide chromosomes evenly (green), enhancing mitochondria, and reducing free radicals https://t.co/nzS2NSsR8p https://t.co/0Ylfm4NjEk
With @LindsayWu_UNSW & team, we showed the NAD booster NMN works to activate SIRT2 and reverse infertility in mice by improving chromosomal stability.