David Sinclair· PhD
A new paper shows that NMN protects the kidneys, reduces cell injury, and suppresses inflammation, immune cell infiltration, and reactive oxygen species in mice receiving chemotherapy.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
A new paper shows that NMN protects the kidneys, reduces cell injury, and suppresses inflammation, immune cell infiltration, and reactive oxygen species in mice receiving chemotherapy.
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Other studies show protection in rodent models of 1. Cisplatin AKI - this and other papers 2. Ischemia-reperfusion injury (AKI/IRI) 3. Post-AKI fibrosis & tubular DNA damage 4. Diabetic nephropathy 5. FSGS / adriamycin nephropathy model 6. Sepsis-associated AKI 7. Heme protein-mediated AKI models