Taking NMN late at night can disrupt circadian rhythms because NAD levels naturally fluctuate throughout the day and control the body's clock. — Whalespan
Taking NMN late at night can disrupt circadian rhythms because NAD levels naturally fluctuate throughout the day and control the body's clock.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“The levels of NAD go up in the morning in our bodies naturally. Our bodies actually have a cycle of NAD, it's not steady. ... In fact, NAD controls your clock. This was shown by Shin Imai and colleagues in this nice science paper about a decade ago, that if you disrupt the NAD cycle, which is controlled by the sirtuin gene that we worked on, that is what's telling your body, oh, it's time to eat, it's time to go to sleep. And if you take these, the NMN late at night, for example, you can disrupt your circadian rhythms.”
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