David Sinclair· PhD
But these other things which are lower blood sugar, improvements in insulin sensitivity, increased mitochondria, those haven't been born out just yet in these short term studies with NR.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
But these other things which are lower blood sugar, improvements in insulin sensitivity, increased mitochondria, those haven't been born out just yet in these short term studies with NR.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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Longitudinal studies that show increases in lifespan as a result of taking NR. But we do have studies that have sought to show similar health benefits to what we've seen in rodents.
But in NR the human studies haven't always confirmed that that's the exact same thing that's happening in humans.
if I recall that study you're talking about showed a few improvements in certain inflammatory markers is that correct right there wasn't much change with DNR it was on some inflammation went down in the muscle and if anything mitochondrial markers of activity were lower we're lower
we do see very subtle changes within our uh that that are aspects of the frailty measurements we in mice or in humans in mice, but it's not enough to really convince us it's statistically significant.