Paul Saladino· MD
if you are taking n R or n MN you better be thinking about your methylation you better be checking homeless cysteine you better be doing that stuff because you are sapping methyl groups with an extra niacin
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
if you are taking n R or n MN you better be thinking about your methylation you better be checking homeless cysteine you better be doing that stuff because you are sapping methyl groups with an extra niacin
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if you really believe that there's substantial evidence that nr nicotinamide riboside or nicotinamide mononucleotide are going to give you longevity benefits then by all means take them but understand that like you probably want to check your b vitamin status and understand your methylation status and your homocysteine you might want to take methylfolate you might want to take betaine which is trimethylglycine because they're going to deplete those things
you know take 250 milligrams of each and and and you'll have a half a gram. You are in a safe relatively safe dose. Follow your homoyine.