NAD precursors like NR and NMN increase NAD levels but lack demonstrated phenotypic benefit in normal or aging individuals outside pathological states.

“as they note in this paper the use of nr nicotinamide riboside or nmn nicotinamide mononucleotide to restore levels of nad has been unreliable they say here however consistency and reliability of such approaches to increase nad plus and also impact on markers of efficacy to slow or reverse features of aging has been inconsistent”

“i think there's evidence that you can take nad precursors nr and nmn being the two most common and increase nad levels i think that has been demonstrated i think two years ago that was not demonstrated as clearly i think what's not been demonstrated is there is any phenotypic benefit from doing that outside of very pathological states in other words if you take a quote-unquote normal person or a normal aging person and do that is it bringing any benefit to them in terms of lifespan or health span and i would say the answer right now is no”

“NR is the last of the three drugs that you mentioned yeah I had high hop so probably more hype with NR than RIS veratrol truthfully on some level somebody's making a lot of money yeah many people are um so tell us about uh tell us about the the findings and what it tells us or doesn't tell us we tested it and it didn't didn't work um that is it didn't extend mouse life span some people said oh well you have to use nmn a metabolite that would have a more bioavailability and better profiles and this is reasonable”