Andrew Huberman· PhD
it's clear to me — based on my read of the data that NR can cross the cell membrane directly directly very easily there's no obstacle to NR getting into cells okay and nmn cannot because of that extra phosphate group
Loading…
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it's clear to me — based on my read of the data that NR can cross the cell membrane directly directly very easily there's no obstacle to NR getting into cells okay and nmn cannot because of that extra phosphate group
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Cells can't take up NAD, they take up precursors (NR, NMN, tryptophan).
when you gave oral NR or n MN the two popular precursors only the liver could make could take them up and make nad using crypto fan no other cell in the body could take it up
both of these can be we know definitively both of these can be brought in to cells to be used as cellular building blocks for nad
there's evidence that there's an NR transporter but either way they both raised in a D levels quite effectively in the body in humans as well
it's not the case that NR needs to be brought into a cell to be turned into nad it's that nicotinamide gets into a cell to be turned into nad
I think that if anything maybe it gets cleaved n R and the NR does I believe the N R gets intact because that's what the Rabinowitz group's paper showed that it was getting into the liver as aa SNR and because it makes sense because then R doesn't have a charged phosphate on it
when you gave oral N R or n MN the two popular precursors only the liver could make could take them up and make nad using tryptophan no other cell in the body could take it up
No, there clearly are some differences um especially in all the really complex biochemistry that happens in terms of getting them into cells.
NR lacks that phosphate and can move into cells through dedicated transporters, where it's naturally converted into NMN and then ultimately NAD This makes NR a cleaner, better studied way to support the NAD network compared to swallowing NAD itself or relying on NMN products of uncertain purity
nicotenomide riboside is not toxic. Um it's an NAD booster. So it's a direct precursor of NAD. The NR can get into cells. >> It can get decorated with the phosphates and converted into its final nucleotide form.
We know it's safe. We know it boosts NAD.