Dogs fed a non-processed, high-fat, raw meat-based diet with organs showed upregulated genes related to lipid metabolism and keratinocyte function, and improvements in skin barrier function, innate immunity, and decreased oxidative stress compared to dogs fed commercial kibble.

“we see the species appropriate diet for dogs a non-processed high-fat food a raw meat diet in dogs and at the end of the diet intervention 149 differentially expect expressed transcripts were found between the atopic and healthy dogs and it was fascinating because they found that all genes were upregulated in the raw diet group and they found that alterations in lipid and keratinocyte metabolism as well as angiogenesis in the skin of atopic dogs and a significant improvement when they moved the dogs from the kibble-based diet to the raw food diet additionally possible enhancement of innate immunity decrease in oxidative stress were seen in raw food-fed dogs which could have played an important role in preventing hypersensitivities and disturbed immunity at a young age”