Andrew Huberman· PhD
So there are nerves in the gut that are sensing the nutrient contents of food and then saying, oh, you should feel better and want more. Oh, that's got a lot of bitterness and acid taste to it. You should want less of that.
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
So there are nerves in the gut that are sensing the nutrient contents of food and then saying, oh, you should feel better and want more. Oh, that's got a lot of bitterness and acid taste to it. You should want less of that.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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In fact, beautiful experiments have been done by the Borges Lab and by other labs showing that even if you numb the mouth, even if you gavavge, which is a really, just a, it's a fancy word for basically tube feeding, you put a tube down into the gut, you just deliver the food to the gut. So you get no opportunity to taste, it sounds pretty awful. If you force feed by gavage, or you numb the mouth, these neurons don't care about the mouth. They only care about the nutrients coming from these foods.