Saponins, like solanine, are plant defense chemicals that can damage the gut, activate the immune system, and lead to inflammation.

“these defense chemicals also occur in things like potatoes solanine is a type of saponin so these are prevalent in the plant kingdom and understanding that these are damaging for your gut and I believe that most human illness begins in the gut they irritate the human gut they cause activation of the immune system they may even bind the tlr4 or tlr5 receptors to like receptors in the gut leading to inflammation Cascades Downstream increasing things like cortisol serotonin or estrogen which are negative in the human body”