Modern Western diets excessively stimulate the anabolic state via mTOR, preventing the body from entering the catabolic state necessary for repair.

“these modern Western diets have basically slammed the accelerator on to growth and never takes into account that we evolved to experience them and some of the benefits that we get from the processes that are turned on when our body is deprived of nutrients is that it cleans out a lot of really bad things toxic proteins misfolded proteins dysfunctional organelles and the reverse of that being essentially over fat over nutrition and keeping him tore this anabolic state of growth turned off on all the time means that we never repair ourselves”