Gut changes from a ketogenic diet can lead to mitochondrial changes in the brain, impacting brain energy metabolism and neurotransmitter function.

“another research group did that same model got mice to have an anti-seizure effect from a ketogenic diet and then dissected their brains looking for what changed in the brain how exactly is a ketogenic diet having an anti-seizure effect in the brain because it that's the pathology the pathological finding seizure is occurring in the brain and when they analyze genetic changes up regulation down regulation it all centered on mitochondria that the changes in the gut were resulting in mitochondrial changes in the brain which means brain energy metabolism in the brain”

“so I I do think we've got more than enough data that ketogenic therapies impact brain metabolism which then impacts neurotransmitters”