Ethanol increases the permeability of the GI tract and activates TLR4 and 5-HT3 receptors.

“ethanol is is notorious number one for increasing the permeability of the of the GI tract and second ethanol itself is an activator of tlr4 in an activator of 5 HD3”

“I remember the study that what they gave animals a 5-ht3 antagonist known as ondansetron and then they gave them basically liberal access to ethanol to the point where 40 or 50 of the calories of the mice came from alcohol they were perfectly fine”