How endotoxins affect your gut health

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Paul Saladino11m · 2023-02-04

Claims Made

31

Claims Supported

26

Support Rate

84%

Support rate

26 of 31 claims supported

26 supported5 partial / not

Claims from this content

28

Not SupportedNo judgment should be made on a person's cardiovascular risk based on their HDL cholesterol level, nor should changing this metric be a therapeutic goal.Well SupportedStarchy foods like bread, potatoes, pasta, and rice are problematic for humans due to gut inflammation and endotoxin production.Well SupportedLPS binding protein (LBP) is a potentially valuable biomarker for chronic systemic inflammation not commonly offered by direct-to-consumer labs.Partially SupportedSoluble CD14 is a reliable biomarker of future mortality in individuals with HIV.Partially Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Ethanol increases the permeability of the GI tract and activates TLR4 and 5-HT3 receptors.

Partially SupportedAntibiotic treatment for SIBO suggests that gut bacteria and their byproducts can be detrimental to health.

Partially SupportedRifaximin can effectively treat SIBO, reduce inflammatory markers, and lower total and LDL cholesterol.

Partially SupportedAnimals with completely sterile guts cannot gain weight, even on a high-fat diet, suggesting a role for gut bacteria in weight regulation.

Partially SupportedPectin is associated with GI cancers and liver cancer.

Partially SupportedHDL cholesterol may be a useful biomarker for heart disease, but its role is complex and has been challenged by drugs that artificially raise HDL.

Partially SupportedAn elevated HDL level may indicate the presence of toxins in the blood.

Partially SupportedSimple sugars from ripe fruits do not appear to cause a pro-bacteria, pro-toxin effect and consuming them freely does not lead to weight gain.

Partially SupportedTo minimize bacterial issues, eat foods that do not mechanically irritate the intestine, are not toxic, and do not feed bacteria.

Partially SupportedPectin likely increases both endotoxin levels and their absorption into the bloodstream, contributing to its carcinogenic effects.

Partially SupportedHdl transports endotoxins from the bloodstream to the liver for neutralization and excretion.

Partially SupportedAn unexplained elevated HDL level may indicate the presence of toxins in the blood.

Partially SupportedGenetics can influence HDL levels and subtypes, making interpretation of HDL as a health marker complex.

Partially SupportedMice consuming 40-50% of their calories from alcohol did not develop liver problems such as fatty liver or fibrotic changes.

Partially SupportedIn individuals with low metabolism or chronic inflammation, bacteria can overgrow into the small intestine, leading to Small Intestinal Bacterial Overgrowth (SIBO).

Partially SupportedSoluble fiber can feed bacteria in the colon and potentially cause imbalances.

Partially SupportedThe ratio of HDL to LDL cholesterol can be a good indicator of health.

Partially SupportedEndotoxin moving from the gut into the bloodstream causes significant health problems.

Partially SupportedIncreasing the number and populations of bacteria in the colon can lead to an increase in gram-negative bacteria and endotoxins.

Partially SupportedFoods like lentils, beans, grains, and starches such as cornstarch and resistant starch from cooked and cooled potatoes can contribute to gut problems.

Partially SupportedRipe fruits contain fiber, flavos, and favonoids that prevent weight gain.

Not SupportedResistant starch may not always be beneficial for the microbiome.

Partially SupportedEasily digestible carbohydrates are preferred over those that feed bacteria extensively as they are absorbed before reaching the colon.

Partially SupportedThe presence of gut bacteria contributes to chronic inflammation with every meal, which should be minimized.