The relationship between dietary cholesterol and serum cholesterol, and its impact on longevity, is complex and not fully understood.

“I cannot, for the life of me, get my arms around this literature. And even if I ignore all the essentially nonsense that's out there in various social media groups, as saying cholesterol is the worst thing in the world, or cholesterol is not, or dietary cholesterol has nothing to do with serum cholesterol and nothing to do with longevity. I can't seem to sort through the very basic data that essentially ask, is having high levels of LDL going to kill me earlier? Should I be striving to always reduce LDL and increase HDL? Is that a reasonable goal? And if so, is dietary cholesterol the primary determinant of that?”