Increased fiber intake may require sufficient microbial diversity to be beneficial, and individuals with depleted microbial diversity may not tolerate increased fiber well.

“And the fiber was much more nuanced. And this is more like a personalized nutrition thing. So, one was a general health recommendation and one was if you're going to go for more fiber, you might need to make sure your microbial diversity is up first. That might be part of what we have to figure out or warn the people with a compromised or depleted microbial diversity that you won't do well right now with more microbes.”