Endocannabinoids may increase in the nucleus accumbens during fasting, driving food-seeking behavior and enhancing food reward.

“for example if an organism doesn't eat for like a day so you f Ed um at that point in those feeding circuits in your brain like the aru area where these arrp neurons and stuff are you'll start seeing elevations in endoc canabo so endoc canabo levels start kind of going up and up um following kind of fasting periods and part of this is because they're trying to engage that feeding circuitry now and they're Shifting the activity of those neurons to promote food-seeking Behavior”