Paul Saladino· MD
this study shows that the colonic epithelium can oxidize both short and long chain fatty acids and that the relationship between the two is dependent on the substrate availability
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
this study shows that the colonic epithelium can oxidize both short and long chain fatty acids and that the relationship between the two is dependent on the substrate availability
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if you block short chain fatty acid oxidation it leads to greater long chain fatty acid used by the colonic epithelial cells
so there are other substrates like isobutyrate or valerate or propionate or long-chain fatty acids that could be there for the clonic epithelial cells