Consuming fat alone, such as butter in coffee, may negatively affect the gut barrier.

“when you just have fat like just fat like putting butter in your coffee you're creaming your coffee like it does seem to be harsh on the gut and a variety of mechanisms have been worked out on that bile acids um which are you know increased for the absorption and digestion of dietary fats um are you know is one thing that's been shown to to basically affect permeability”