Andrew Huberman· PhD
Oh yeah, the ketogenic diet, in many cases, not all, "can be very effective for this treatment.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Oh yeah, the ketogenic diet, in many cases, not all, "can be very effective for this treatment.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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But the ketogenic diet, by way of increasing ketone metabolism or shifting brain's metabolism over to ketones tends to modulate GABA such that GABA is more active and adjust the so-called GABA glutamate balance.
How? How is it that a ketogenic diet reduces seizures? Well, the way it reduces seizures is by increasing what's called GABA transmission. GABA is a substance that is naturally released in our brain. It's an inhibitory neurotransmitter, meaning that when it's released into the synapse, it has the tendency to reduce the firing, to reduce the electrical activity of the next neuron or sets of neurons.
The reason why the epileptic diet is useful for epilepsy is that increases what we call the tonic level, the sort of the ti, the level of GABA in the brain, and that suppresses some of the hyperexcitability, that is the characteristic feature of epilepsy.
I think that Kido is a very hypothesis driven way to replace the drugs that were available at that time
So, you know, the ketogenic diet, one thing it seems to do is enhance activity of what's called an inhibitory neurotransmitter called GABA.