The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
fructose in its pure form is often not absorbed very well so what winds up happening is the fructose gets left inside the intestine and then bacteria are able to capitalize on that fructose inside the intestine and then they start to create bacterial products and one of the major ones is called endotoxin or lipop polyat
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this doesn't happen when you give someone a fruit or honey which have a Whole Food's Matrix they have all of the polyphenols thousands of other chemicals which actually prevent overgrowth of bacteria in our gut these these polyphenols these chemicals prevent the biosis
when you give humans pure fructose which never occurs in nature or pure sucrose they get overgrowth of the bacteria in their gut and that causes dysbiosis and you get endotoxemia increase lip a polysaccharide
And there's plenty of studies that show that if you give a human or you give a mouse pure glucose, pure fructose or pure sugar, you will get something called endotoxmia. Metabolic endotoxmia.
I think the reason that processed sugar is bad for us is not necessarily because it raises our blood sugar, but because it messes with our gut flora. It causes overgrowth of the wrong bacteria, causes dispiosis, which leads to increased lipopolyaccharide in the human body.