Andrew Huberman· PhD
but it seems like both pufas and mufas are better than saturated fat in terms of metabolic health and uh risk of C vascular disease those sorts of things
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but it seems like both pufas and mufas are better than saturated fat in terms of metabolic health and uh risk of C vascular disease those sorts of things
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if you look at the cohort data polyunsaturated fats substituted for saturated fats have a stronger effect on reducing heart disease than than monounsaturated fats
there was a meta analysis I think in 2017 where they put together all the trials that looked at there were human randomized control trials looking at substitution of polyunsaturated fats for saturated fats not confounded by trans fat. This was a very clear benefit to substitution. I think it was around 20% reduced mortality risk.
Monounsaturated fats, there appears to be a reduction in risk of cardiovascular disease. It appears to be not quite as powerful at least in the cohort studies as polyunsaturated fats.
there was one really big cohort metaanalysis that was done that kind of showed that monounsaturated didn't have as big of an effect as polyunsaturated as decreasing the risk of cardiovascular disease that monounsaturated was still positive and saturated was negative but polyunsaturated was kind of better in a dose response