Signals from fat-free mass, which is a determinant of resting metabolic rate, likely play a role in regulating food intake, though the specific signals are still being investigated.

“we need to think that we have also signals coming from the fat-free Mass now what is the fat free Mass you know we measure it as everything but the fat and we call that fat free Mass but you know it's liver it's uh it's muscle skeletal muscle it's everything but the fat and I think that there are signals that we are still chasing you know John blundel showed that we eat according to our fat free Mass which is basically we eat according to our resting metabolic rate because fat freeass is the m determinant of your resting metabolic rate but what are the signals I don't know”