Andrew Huberman· PhD
but fructose nitrates tight Junction proteins now let me explain that to your audience your intestine is a sewer definition of a sewer a pipe with in it okay that's a sewer our intestines are sewers there's junk in the center and the job of the intestine is to move the junk through to the anus absorbing the good stuff while you can the intestine is made up of cells intestinal epithelial cells that are bound together and they're bound with proteins that basically form a barrier those barriers are called tight Junction proteins things like cloudin and things like that um zulin is the main one okay there are others but zulin is the one that goes is defective in the celiac disease what defines a tight Junction is it is like completely impermeable or semi-permeable completely impermeable okay unless its function is inhibited turns out if you alter the um uh phosphorilation status or the nitrate status of that tight Junction it will become transiently permeable okay and so fructose nitrates tight Junction proteins causing them to be transiently permeable allowing some of the junk in your intestine to get through into your bloodstream so this is leaky gut this is leaky gut this is what causes leaky gut fructose is a driver of leaky gut